My Blogs and Thoughts

Random variation is no longer the basis for survival-of-the-fittest, but designed/tested variation is, with global optima replacing the paradoxical inefficiencies of local optima

"Their is nothing necessarily efficient, optimal or sustainable in ecology. Plenty of ecological systems are entirely unsustainable, suboptimal and inefficient, even where no human influence has been injected into the system. Nature is messy, amoral, antiteleologic, exceedingly variable and incredibly focused locally and temporally. None of these are things that we want to build into our IT or business systems" -Marc d. Paradis
OMG Business Ecology Initiative

A Tale of Two Achilles' Heels

Privacy, Logistics and Dark Data issues - wait that's three Achilles' Heels...

Data has Become Too Distributed to Secure
How Netflix is Destroying Your Privacy
Hacking of SSNs with Birthday and Birth Zip
When 2+2 Equals a Privacy Question
Data Security Status at Healthcare Organizations (Details here)

Heads, Tails and Shoulders

Patient competency is on a curve, CER/EBM/P4P breaks on the shoulders and washes on the tails

P=NP

Precision medicine may be an NP problem

Content, Connection, Context

Web 1.0 is content, Web 2.0/Semantic Web is Connection, Web 3.0 is Context

How to Make Comparitive Effectiveness Research Completely Ineffective

Weaknesses of CER and how to fix them

Why 'Quality' Care is Dangerous

A Generalizable List of Architectural Best Practices

A collection of best practices and principles which generalize across all (or most) modern architectural disciplines (EA, IA, DA, BA, NA, even Building Architecture)

TOGAF v9 Management Overview

ROI, ROM, ROV, R-O-What?

A discussion of what an appropriate measure of return in non-financial endeavors e.g. healthcare, government, etc.

Analytics Without Analysts

Beware Predictive Analytics hype, powerful technology but people's skills and organizational cultures are not yet ready

Instrumenting Your Enterprise
You Built It, You Break It
All Business Analysts Are Not Created Equal
Why Has Data Mining Struggled So Much?
What's Up with Cloud Analytics?
Why We Should Teach Programming to All Students
If you can understand and implement Part I and Part II, you deserve to be an Analyst

With People This Smart, How Can We Be Wrong?

A discussion of how really smart people who are always right, can be so very wrong (sometimes)

Retrocogitator Puzzle Masters Revealed
Issues of Framing and Influence (also germane to basic data theory)

Published Papers

"The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily" JBC (Oct 1994)

"Rapid induction of Alzheimer A beta amyloid formation by zinc" Science (Sep 1994)

"Modulation of A beta adhesiveness and secretase site cleavage by zinc" JBC (Apr 1994)

"Genetic heterogeneity of gene defects responsible for familial Alzheimer disease" Genetica (1993)

"Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor" Nat Genetics (Sep 1993)